The formulation offers a synergistic action of active principle with other natural ingredients in controlling Diabetes Mellitus as a whole which has been proven experimentally.
This combination has not only the potent anti-diabetic action but also prevents and cures different complications of diabetes like neuropathy, nephropathy and vasculopathy which are the main complications and side effects of diabetic patients which has been proved by clinical trial amongst NIDDM patients. Thus along with correcting the blood sugar level and body resistance it also corrects the metabolic derangements and hence prevents the man from the side effects and other complications of modern synthetic anti- diabetic drug.
Mechanism of action:
The active principle controls diabetes in the following manner:
* Epicatechin increases the cAMP content of the islet which is associated with increased insulin release.
* Epicatechin plays a role in the conversion of proinsulin to insulin by increasing cathepsin ß activity.
* Epicatechin plays an insulin-mimetic effect on osmotic fragility of human erythrocytes.
* Epicatechin inhibits Na/K ATPase activity on patient erythrocytes, an effect similar to that of insulin.
Dosage and administration
One capsule twice daily half an hour before principal meals for the newly diagnosed NIDDM patients. If the patient is suffering from chronic or severe diabetes Episulin may be included in the treatment at a higher dose 2-3 capsules twice to thrice daily minimum half an hour before meals without stopping the modern / synthetic drugs. These synthetic drugs may be gradually tapered down with the regular monitoring of blood sugar level and patients own feeling of well being. Effect of Episulin may reach to a level when gradually synthetic drugs may not be required then gradually high dose of Episulin is brought down to the maintenance dose of 2 capsules BD (twice daily) before meals.
Effect of Episulin differs from patient to patient due to difference in physiological, physical, social, familial and dietary conditions.
Although so far no adverse reaction or result has been reported, chronic and severe diabetic patients are advised to consult their physician for dose management and treatment method.
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